Serum bicarbonate concentrations and kidney disease progression in community-living elders: the Health, Aging, and Body Composition (Health ABC) Study.

ABSTRACT:

Background

In populations with prevalent chronic kidney disease (CKD), lower serum bicarbonate levels are associated with more rapid CKD progression, but whether lower bicarbonate levels also are associated with risk of incident estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m(2) and CKD progression among community-living persons with predominantly preserved kidney function is unknown.

Study design

Longitudinal observational cohort study.

Setting & participants

Well-functioning community-living elders aged 70-79 years at inception.

Predictor

Serum bicarbonate level measured at the time of collection by arterialized venous blood sample using an arterial blood gas analyzer.

Outcomes

Change in eGFR over 7 years, and new eGFR < 60 mL/min/1.73 m

SUBMITTER: Goldenstein L 

PROVIDER: S-EPMC4177317 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature