Contributions of familial rheumatoid arthritis or lupus and environmental factors to risk of rheumatoid arthritis in women: a prospective cohort study.

ABSTRACT:

Objective

We assessed the contributions of familial rheumatoid arthritis (RA) or lupus and environmental factors to the risk of RA.

Methods

Among 121,700 women in the Nurses' Health Study, 65,457 provided data on familial RA/lupus. Among these, 493 RA cases (301 seropositive and 192 seronegative) were validated. We estimated hazard ratios (HRs) for RA comparing those with and without familial RA/lupus, adjusting for environmental factors (smoking, alcohol, body mass index [BMI], parity, breastfeeding, menopause, hormone use, early menarche, and menstrual regularity) using Cox proportional hazards models. Population attributable risks (PARs) for RA within this cohort were calculated for familial RA/lupus, smoking, alcohol, BMI, parity, and breastfeeding.

Results

Famili

SUBMITTER: Sparks JA 

PROVIDER: S-EPMC4177324 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature