Community differentiation of the cutaneous microbiota in psoriasis.

ABSTRACT:

Background

Psoriasis is a common chronic inflammatory disease of the skin. We sought to characterize and compare the cutaneous microbiota of psoriatic lesions (lesion group), unaffected contralateral skin from psoriatic patients (unaffected group), and similar skin loci in matched healthy controls (control group) in order to discern patterns that govern skin colonization and their relationship to clinical diagnosis.

Results

Using high-throughput 16S rRNA gene sequencing, we assayed the cutaneous bacterial communities of 51 matched triplets and characterized these samples using community data analysis techniques. Intragroup Unifrac β diversity revealed increasing diversity from control to unaffected to lesion specimens. Likewise, principal coordinates analysis (PCoA) revealed

SUBMITTER: Alekseyenko AV 

PROVIDER: S-EPMC4177411 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature