Novel expression of EGFL7 in placental trophoblast and endothelial cells and its implication in preeclampsia.

ABSTRACT: The mammalian placenta is the site of nutrient and gas exchange between the mother and fetus, and is comprised of two principal cell types, trophoblasts and endothelial cells. Proper placental development requires invasion and differentiation of trophoblast cells, together with coordinated fetal vasculogenesis and maternal vascular remodeling. Disruption in these processes can result in placental pathologies such as preeclampsia (PE), a disease characterized by late gestational hypertension and proteinuria. Epidermal Growth Factor Like Domain 7 (EGFL7) is a largely endothelial-restricted secreted factor that is critical for embryonic vascular development, and functions by modulating the Notch signaling pathway. However, the role of EGFL7 in placental development remains unknown. In this st

SUBMITTER: Lacko LA 

PROVIDER: S-EPMC4177412 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature