TNFα and IL-1β influence the differentiation and migration of murine MSCs independently of the NF-κB pathway.

ABSTRACT:

Introduction

Mesenchymal stem cells (MSCs) have the ability to repair and regenerate tissue, home to sites of inflammation, and evade the host immune system. As such, they represent an attractive therapy for the treatment of autoimmune inflammatory diseases. However, results from in vivo murine studies in inflammatory arthritis have been conflicting, and this may be due to the genetic background of the MSCs used. It is known that the inflammatory milieu may influence properties of MSCs and that, in the case of human bone marrow-derived MSCs, this may be mediated by the nuclear factor-kappa-B (NF-κB) pathway. We sought to determine whether pro-inflammatory cytokines altered the differentiation and migration capacity of murine MSCs from different mouse strains and whether this was me

SUBMITTER: Sullivan CB 

PROVIDER: S-EPMC4177434 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature