5-HTTLPR moderates naltrexone and psychosocial treatment responses in heavy drinking men who have sex with men.

ABSTRACT:

Background

A functional polymorphism (5-HTTLPR) in the promoter region of the serotonin transporter gene has been widely studied as a risk factor and moderator of treatment for a variety of psychopathologic conditions. To evaluate whether 5-HTTLPR moderates the effects of treatment to reduce heavy drinking, we studied 112 high-functioning European-American men who have sex with men (MSM). Subjects participated in a randomized clinical trial of naltrexone (NTX) and cognitive behavioral therapy (CBT) for problem drinking.

Methods

Subjects were treated for 12 weeks with 100 mg/d of oral NTX or placebo (PBO). All participants received medical management with adjusted brief behavioral compliance enhancement treatment (BBCET) alone or in combination with modified behavioral self-c

SUBMITTER: Chen AC 

PROVIDER: S-EPMC4177453 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature