Murine norovirus infection does not cause major disruptions in the murine intestinal microbiota.

ABSTRACT:

Background

Murine norovirus (MNV) is the most common gastrointestinal pathogen of research mice and can alter research outcomes in biomedical mouse models of inflammatory bowel disease (IBD). Despite indications that an altered microbiota is a risk factor for IBD, the response of the murine intestinal microbiota to MNV infection has not been examined. Microbiota disruption caused by MNV infection could introduce the confounding effects observed in research experiments. Therefore, this study investigated the effects of MNV infection on the intestinal microbiota of wild-type mice.

Results

The composition of the intestinal microbiota was assessed over time in both outbred Swiss Webster and inbred C57BL/6 mice following MNV infection. Mice were infected with both persistent and

SUBMITTER: Nelson AM 

PROVIDER: S-EPMC4177540 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature