Whole gene expression profile in blood reveals multiple pathways deregulation in R6/2 mouse model.

ABSTRACT:

Background

Huntington Disease (HD) is a progressive neurological disorder, with pathological manifestations in brain areas and in periphery caused by the ubiquitous expression of mutant Huntingtin protein. Transcriptional dysregulation is considered a key molecular mechanism responsible of HD pathogenesis but, although numerous studies investigated mRNA alterations in HD, so far none evaluated a whole gene expression profile in blood of R6/2 mouse model.

Findings

To discover novel pathogenic mechanisms and potential peripheral biomarkers useful to monitor disease progression or drug efficacy, a microarray study was performed in blood of R6/2 at manifest stage and wild type littermate mice. This approach allowed to propose new peripheral molecular processes involved in HD and

SUBMITTER: Diamanti D 

PROVIDER: S-EPMC4177605 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature