Differential management of the replication terminus regions of the two Vibrio cholerae chromosomes during cell division.

ABSTRACT: The replication terminus region (Ter) of the unique chromosome of most bacteria locates at mid-cell at the time of cell division. In several species, this localization participates in the necessary coordination between chromosome segregation and cell division, notably for the selection of the division site, the licensing of the division machinery assembly and the correct alignment of chromosome dimer resolution sites. The genome of Vibrio cholerae, the agent of the deadly human disease cholera, is divided into two chromosomes, chrI and chrII. Previous fluorescent microscopy observations suggested that although the Ter regions of chrI and chrII replicate at the same time, chrII sister termini separated before cell division whereas chrI sister termini were maintained together at mid-cell, wh

SUBMITTER: Demarre G 

PROVIDER: S-EPMC4177673 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature