Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection.

ABSTRACT:

Background

The obligate intracellular parasite Toxoplasma gondii establishes a life-long chronic infection within any warm-blooded host. After ingestion of an encysted parasite, T. gondii disseminates throughout the body as a rapidly replicating form during acute infection. Over time and after stimulation of the host immune response, T. gondii differentiates into a slow growing, cyst form that is the hallmark of chronic infection. Global transcriptome analysis of both host and parasite during the establishment of chronic T. gondii infection has not yet been performed. Here, we conducted a dual RNA-seq analysis of T. gondii and its rodent host to better understand host and parasite responses during acute and chronic infection.

Results

We obtained nearly one billion paired-end

SUBMITTER: Pittman KJ 

PROVIDER: S-EPMC4177681 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature