Evolution and genomic organization of muscle microRNAs in fish genomes.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small non-coding RNA molecules with an important role upon post-transcriptional regulation. These molecules have been shown essential for several cellular processes in vertebrates, including muscle biology. Many miRNAs were described as exclusively or highly expressed in skeletal and/or cardiac muscle. However, knowledge on the genomic organization and evolution of muscle miRNAs has been unveiled in a reduced number of vertebrates and mostly only reflects their organization in mammals, whereas fish genomes remain largely uncharted. The main goal of this study was to elucidate particular features in the genomic organization and the putative evolutionary history of muscle miRNAs through a genome-wide comparative analysis of cartilaginous and bony fis

SUBMITTER: Nachtigall PG 

PROVIDER: S-EPMC4177693 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature