Genotyping of Burkholderia mallei from an outbreak of glanders in Bahrain suggests multiple introduction events.

ABSTRACT:

Background

Glanders, caused by the gram-negative bacterium Burkholderia mallei, is a highly infectious zoonotic disease of solipeds causing severe disease in animals and men. Although eradicated from many Western countries, it recently emerged in Asia, the Middle-East, Africa, and South America. Due to its rareness, little is known about outbreak dynamics of the disease and its epidemiology.

Methodology/principal findings

We investigated a recent outbreak of glanders in Bahrain by applying high resolution genotyping (multiple locus variable number of tandem repeats, MLVA) and comparative whole genome sequencing to B. mallei isolated from infected horses and a camel. These results were compared to samples obtained from an outbreak in the United Arab Emirates in 2004, and furt

SUBMITTER: Scholz HC 

PROVIDER: S-EPMC4177748 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature