Reduction of specific circulating lymphocyte populations with metabolic risk factors in patients at risk to develop type 2 diabetes.

ABSTRACT: Low-grade inflammation, characterized by increased pro-inflammatory cytokine levels, is present in patients with obesity-linked insulin resistance, hyperglycemia and hyperlipidemia and considered to play a leading role to progression into type 2 diabetes (T2D). In adipose tissue in obese patients and in pancreatic islets in T2D patients cellular inflammation is present. However, the systemic leukocyte compartment and the circulating endothelial/precursor compartment in patients at risk to develop T2D has so far not been analyzed in detail. To address this, peripheral blood cells from a cohort of 20 subjects at risk to develop diabetes with normal to impaired glucose tolerance were analyzed by flow cytometry using a wide range of cellular markers and correlated to known metabolic risk facto

SUBMITTER: Cucak H 

PROVIDER: S-EPMC4177835 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature