Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection.

ABSTRACT: Resistance and susceptibility to Leishmania major infection in the murine model is determined by the capacity of the host to mount either a protective Th1 response or a Th2 response associated with disease progression. Previous reports involving the use of cysteine cathepsin inhibitors indicated that cathepsins B (Ctsb) and L (Ctsl) play important roles in Th1/Th2 polarization during L. major infection in both susceptible and resistant mouse strains. Although it was hypothesized that these effects are a consequence of differential patterns of antigen processing, the mechanisms underlying these differences were not further investigated. Given the pivotal roles that dendritic cells and macrophages play during Leishmania infection, we generated bone-marrow derived dendritic cells (BMDC) and m

SUBMITTER: Gonzalez-Leal IJ 

PROVIDER: S-EPMC4177854 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature