A randomized clinical trial comparing methotrexate and mycophenolate mofetil for noninfectious uveitis.

ABSTRACT:

Objective

To compare the relative effectiveness of methotrexate and mycophenolate mofetil for noninfectious intermediate uveitis, posterior uveitis, or panuveitis.

Design

Multicenter, block-randomized, observer-masked clinical trial.

Participants

Eighty patients with noninfectious intermediate, posterior, or panuveitis requiring corticosteroid-sparing therapy at Aravind Eye Hospitals in Madurai and Coimbatore, India.

Intervention

Patients were randomized to receive 25 mg weekly oral methotrexate or 1 g twice daily oral mycophenolate mofetil and were monitored monthly for 6 months. Oral prednisone and topical corticosteroids were tapered.

Main outcome measures

Masked examiners assessed the primary outcome of treatment success, defined by achieving the fol

SUBMITTER: Rathinam SR 

PROVIDER: S-EPMC4177935 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature