Cigarette smoking and the natural history of age-related macular degeneration: the Beaver Dam Eye Study.

ABSTRACT:

Purpose

To examine the association of current cigarette smoking and pack-years smoked with the incidence and progression of age-related macular degeneration (AMD) and to examine the interactions of current smoking and pack-years smoked with complement factor H (CFH, rs1061170) and age-related maculopathy susceptibility 2 (ARMS2, rs10490924) genotype.

Design

A longitudinal population-based study of AMD in a representative American community. Examinations were performed every 5 years over a 20-year period.

Participants

A total of 4439 participants in the population-based Beaver Dam Eye Study (BDES).

Methods

Age-related macular degeneration status was determined from grading retinal photographs. Multi-state models were used to model the relationship of current smo

SUBMITTER: Myers CE 

PROVIDER: S-EPMC4177947 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature