Automated gait and balance parameters diagnose and correlate with severity in Parkinson disease.

ABSTRACT:

Objective

To assess the suitability of instrumented gait and balance measures for diagnosis and estimation of disease severity in PD.

Methods

Each subject performed iTUG (instrumented Timed-Up-and-Go) and iSway (instrumented Sway) using the APDM(®) Mobility Lab. MDS-UPDRS parts II and III, a postural instability and gait disorder (PIGD) score, the mobility subscale of the PDQ-39, and Hoehn & Yahr stage were measured in the PD cohort. Two sets of gait and balance variables were defined by high correlation with diagnosis or disease severity and were evaluated using multiple linear and logistic regressions, ROC analyses, and t-tests.

Results

135 PD subjects and 66 age-matched controls were evaluated in this prospective cohort study. We found that both iTUG and iSway vari

SUBMITTER: Dewey DC 

PROVIDER: S-EPMC4177980 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature