SDT: a virus classification tool based on pairwise sequence alignment and identity calculation.

ABSTRACT: The perpetually increasing rate at which viral full-genome sequences are being determined is creating a pressing demand for computational tools that will aid the objective classification of these genome sequences. Taxonomic classification approaches that are based on pairwise genetic identity measures are potentially highly automatable and are progressively gaining favour with the International Committee on Taxonomy of Viruses (ICTV). There are, however, various issues with the calculation of such measures that could potentially undermine the accuracy and consistency with which they can be applied to virus classification. Firstly, pairwise sequence identities computed based on multiple sequence alignments rather than on multiple independent pairwise alignments can lead to the deflation of

SUBMITTER: Muhire BM 

PROVIDER: S-EPMC4178126 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature