Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis.

ABSTRACT:

Background

Chloroquine is the first-line treatment for Plasmodium vivax malaria in most endemic countries, but resistance is increasing. Monitoring of antimalarial efficacy is essential, but in P. vivax infections the assessment of treatment efficacy is confounded by relapse from the dormant liver stages. We systematically reviewed P. vivax malaria treatment efficacy studies to establish the global extent of chloroquine resistance.

Methods

We searched Medline, Web of Science, Embase, and the Cochrane Database of Systematic Reviews to identify studies published in English between Jan 1, 1960, and April 30, 2014, which investigated antimalarial treatment efficacy in P. vivax malaria. We excluded studies that did not include supervised schizonticidal treatment without primaquin

SUBMITTER: Price RN 

PROVIDER: S-EPMC4178238 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature