Identifying the interaction between influenza and pneumococcal pneumonia using incidence data.

ABSTRACT: The association between influenza virus and the bacterium Streptococcus pneumoniae (pneumococcus) has been proposed as a polymicrobial system, whereby transmission and pathogenicity of one pathogen (the bacterium) are affected by interactions with the other (the virus). However, studies focusing on different scales of resolution have painted an inconsistent picture: Individual-scale animal experiments have unequivocally demonstrated an association, whereas epidemiological support in human populations is, at best, inconclusive. We integrate weekly incidence reports and a mechanistic transmission model within a likelihood-based inference framework to characterize the nature, timing, and magnitude of this interaction. We find support for a strong but short-lived interaction, with influenza in

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC4178309 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature