Immunogenicity of a synthetic vaccine based on Plasmodium vivax Duffy binding protein region II.

ABSTRACT: Molecules that play a role in Plasmodium merozoite invasion of host red blood cells represent attractive targets for blood-stage vaccine development against malaria. In Plasmodium vivax, merozoite invasion of reticulocytes is mediated by the Duffy binding protein (DBP), which interacts with its cognate receptor, the Duffy antigen receptor for chemokines, on the surface of reticulocytes. The DBP ligand domain, known as region II (DBPII), contains the critical residues for receptor recognition, making it a prime target for vaccine development against blood-stage vivax malaria. In natural infections, DBP is weakly immunogenic and DBPII allelic variation is associated with strain-specific immunity, which may compromise vaccine efficacy. In a previous study, a synthetic vaccine termed DEKnull t

SUBMITTER: Ntumngia FB 

PROVIDER: S-EPMC4178564 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature