Evidence for widespread positive and negative selection in coding and conserved noncoding regions of Capsella grandiflora.

ABSTRACT: The extent that both positive and negative selection vary across different portions of plant genomes remains poorly understood. Here, we sequence whole genomes of 13 Capsella grandiflora individuals and quantify the amount of selection across the genome. Using an estimate of the distribution of fitness effects, we show that selection is strong in coding regions, but weak in most noncoding regions, with the exception of 5' and 3' untranslated regions (UTRs). However, estimates of selection on noncoding regions conserved across the Brassicaceae family show strong signals of selection. Additionally, we see reductions in neutral diversity around functional substitutions in both coding and conserved noncoding regions, indicating recent selective sweeps at these sites. Finally, using expression

SUBMITTER: Williamson RJ 

PROVIDER: S-EPMC4178662 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature