Carbohydrate coating reduces adhesion of biofilm-forming Bacillus subtilis to gold surfaces.

ABSTRACT: The growth of bacterial biofilms in pipes and food tanks causes severe problems in industry. Biofilms growing on medical implants or catheters are of great concern, as they can cause serious infections and decrease the functionality of the medical device. The prevention of bacterial adhesion--the first step in colonization and biofilm formation--is therefore very important. Current research comprises alterations in surface properties, the prevention of adhesin biosynthesis, inhibition with receptor analogs, or the development of anti-adhesive vaccines. We present a new approach that allows us to study bacterial adhesion with high sensitivity in real-time while testing several different surfaces in parallel. Using the cantilever-array technique we demonstrate that coating of gold surfaces w

SUBMITTER: Kesel S 

PROVIDER: S-EPMC4178664 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature