Comparison of genotypes I and III in Japanese encephalitis virus reveals distinct differences in their genetic and host diversity.

ABSTRACT:

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Japanese encephalitis (JE) is an arthropod-borne disease associated with the majority of viral encephalitis cases in the Asia-Pacific region. The causative agent, Japanese encephalitis virus (JEV), has been phylogenetically divided into five genotypes. Recent surveillance data indicate that genotype I (GI) is gradually replacing genotype III (GIII) as the dominant genotype. To investigate the mechanism behind the genotype shift and the potential consequences in terms of vaccine efficacy, human cases, and virus dissemination, we collected (i) all full-length and partial JEV molecular sequences and (ii) associated genotype and host information comprising a data set of 873 sequences. We then examined differences between the two genotypes at the genetic and epidemiological l

SUBMITTER: Han N 

PROVIDER: S-EPMC4178791 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature