Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.

ABSTRACT: The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function.

SUBMITTER: Tran EE 

PROVIDER: S-EPMC4178867 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature