Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.

ABSTRACT:

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Influenza viral infection represents a serious public health problem that causes contagious respiratory disease, which is most effectively prevented through vaccination to reduce transmission and future infection. The nonstructural (NS) gene of influenza A virus encodes an mRNA transcript that is alternatively spliced to express two viral proteins, the nonstructural protein 1 (NS1) and the nuclear export protein (NEP). The importance of the NS gene of influenza A virus for viral replication and virulence has been well described and represents an attractive target to generate live attenuated influenza viruses with vaccine potential. Considering that most amino acids can be synthesized from several synonymous codons, this study employed the use of misrepresented mammalian

SUBMITTER: Nogales A 

PROVIDER: S-EPMC4178899 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature