DNA methylation dynamics of the human preimplantation embryo.

ABSTRACT: In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distributed across the genome, with local, cell-type-specific regulation directed by DNA binding factors. This comparatively static landscape is in marked contrast with the events of fertilization, during which the paternal genome is globally reprogrammed. Paternal genome demethylation includes the majority of CpGs, although methylation remains detectable at several notable features. These dynamics have been extensively characterized in the mouse, with only limited observations available in other mammals, and direct measurements are required to understand the extent to which early embryonic landscapes are conserved. We present genome-scale DNA methylation maps of human preimplantation development a

SUBMITTER: Smith ZD 

PROVIDER: S-EPMC4178976 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature