Associations between estrogen receptor-beta polymorphisms and endometriosis risk: a meta-analysis.

ABSTRACT:

Background

Many epidemiological studies have suggested an association between estrogen receptor-beta (ER-β) polymorphisms with endometriosis risk. However, the results of these studies have been inconsistent. In the present study, we performed a meta-analysis to clarify the associations between the ER-β rs4986938 and rs1256049 polymorphisms and endometriosis risk.

Methods

Eligible publications were retrieved from the PubMed, ISI Web of Science, and several Chinese language databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random or fixed effect model.

Results

A total of eight studies (1100 cases/1485 controls) for the rs4986938 polymorphism and four studies (353 cases/450 controls) for the rs1256049 polymorphism were inclu

SUBMITTER: Guo R 

PROVIDER: S-EPMC4179845 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature