Interactions between adiposity and genetic polymorphisms on the risk of psoriasis.

ABSTRACT:

Background

Adiposity is a known risk factor for psoriasis. Genome-wide association studies (GWAS) have identified a number of genes associated with risk of psoriasis while the evidence on gene-environment interactions in psoriasis is very sparse.

Objectives

To investigate the effect modification by adiposity measures on the association between single-nucleotide polymorphisms (SNPs) from published GWAS and risk of psoriasis.

Methods

Our psoriasis GWAS dataset comprised 9194 participants, including 337 individuals with psoriasis and 8857 controls from six GWAS, nested within the Nurses' Health Study (NHS), NHS II, and Health Professionals' Follow-up Study. Clinician-diagnosed psoriasis was ascertained with high validity. For stratified analyses, body mass index (BMI) wa

SUBMITTER: Li WQ 

PROVIDER: S-EPMC4179882 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature