Fluoxetine treatment ameliorates depression induced by perinatal arsenic exposure via a neurogenic mechanism.

ABSTRACT: Several epidemiological studies have reported an association between arsenic exposure and increased rates of psychiatric disorders, including depression, in exposed populations. We have previously demonstrated that developmental exposure to low amounts of arsenic induces depression in adulthood along with several morphological and molecular aberrations, particularly associated with the hippocampus and the hypothalamic-pituitary-adrenal (HPA) axis. The extent and potential reversibility of this toxin-induced damage has not been characterized to date. In this study, we assessed the effects of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on adult animals exposed to arsenic during development. Perinatal arsenic exposure (PAE) induced depressive-like symptoms in a mild l

SUBMITTER: Tyler CR 

PROVIDER: S-EPMC4180420 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature