The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.

ABSTRACT: During cell division, cells form the microtubule-based mitotic spindle, a highly specialized and dynamic structure that mediates proper chromosome transmission to daughter cells. Cancer cells can show perturbed mitotic spindles and an approach in cancer treatment has been to trigger cell killing by targeting microtubule dynamics or spindle assembly. To identify and characterize proteins necessary for spindle assembly, and potential antimitotic targets, we performed a proteomic and genetic analysis of 592 mitotic microtubule copurifying proteins (MMCPs). Screening for regulators that affect both mitosis and apoptosis, we report the identification and characterization of STARD9, a kinesin-3 family member, which localizes to centrosomes and stabilizes the pericentriolar material (PCM). STARD9

SUBMITTER: Torres JZ 

PROVIDER: S-EPMC4180425 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature