Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation.

ABSTRACT:

Background

Statins are widely prescribed for lowering LDL-cholesterol (LDLC) levels and risk of cardiovascular disease. There is, however, substantial inter-individual variation in the magnitude of statin-induced LDLC reduction. To date, analysis of individual DNA sequence variants has explained only a small proportion of this variability. The present study was aimed at assessing whether transcriptomic analyses could be used to identify additional genetic contributions to inter-individual differences in statin efficacy.

Results

Using expression array data from immortalized lymphoblastoid cell lines derived from 372 participants of the Cholesterol and Pharmacogenetics clinical trial, we identify 100 signature genes differentiating high versus low statin responders. A radial-b

SUBMITTER: Kim K 

PROVIDER: S-EPMC4180544 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature