Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.

ABSTRACT:

Background

A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape.

Results

Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef.

Conclusions

Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to t

SUBMITTER: Ritchie AJ 

PROVIDER: S-EPMC4180588 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature