Circulating collagen biomarkers as indicators of disease severity in pulmonary arterial hypertension.

ABSTRACT:

Objectives

The goal of this study was to determine if biomarkers of collagen metabolism in PAH identify patients with worse disease and higher risk of death.

Background

The relationship between circulating markers of collagen metabolism, degree of disease severity, and outcome in pulmonary arterial hypertension (PAH) is unknown.

Methods

Patients with stable idiopathic, anorexigen-associated, and hereditary PAH were prospectively enrolled. Levels of the following collagen biomarkers were measured: N-terminal pro-peptide of type III procollagen (PIIINP), C-terminal telopeptide of collagen type I (CITP), matrix metalloproteinase (MMP)-9, and tissue inhibitor of metalloproteinase (TIMP)-1. Patients were divided into mild, moderate, and severe PAH groups. Data were compare

SUBMITTER: Safdar Z 

PROVIDER: S-EPMC4180669 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature