Duration of obesity and overweight and risk of type 2 diabetes among US women.

ABSTRACT:

Objective

The purpose of this study was to examine the association between duration of adiposity and risk of type 2 diabetes (T2D) in US women.

Methods

Nearly 61,821 participants were prospectively followed from the Nurses' Health Study (1984-2008) and 63,653 participants from Nurses' Health Study II (1991-2011). Participants were considered overweight (BMI 25-30 kg m(-2) ) or obese (BMI ≥ 30 kg m(-2) ) if their BMI was above the cutoffs for two successive assessments. The time-dependent Cox proportional hazard models were used to assess associations between excess weight duration and T2D risk.

Results

In pooled multivariable analyses of the two cohorts, each two extra years of being overweight was associated with 9% (RR = 1.09, 95% CI 1.08-1.09) increased risk of dev

SUBMITTER: Hu Y 

PROVIDER: S-EPMC4180760 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature