Expression of antisense small RNAs in response to stress in Pseudomonas aeruginosa.

ABSTRACT:

Background

RNA sequencing technologies reveal that bacteria express RNA molecules other than mRNA, rRNA or tRNA. During the last years genome-wide bacterial transcriptomes have been shown to comprise intergenic RNA, antisense RNA, and untranslated regions, all capable of performing diverse regulatory functions.

Results

In this study we used RNA-seq to identify 232 antisense RNAs (asRNAs) in the opportunistic pathogen Pseudomonas aeruginosa grown under 13 different conditions. The conditions studied include exponential and stationary growth as well as osmotic, oxidative and antibiotic stress. We found a significant overrepresentation of asRNAs that are transcribed opposite to genes involved in cell division and in cell wall, lipopolysaccharide (LPS), and capsule biosynthesis,

SUBMITTER: Gomez-Lozano M 

PROVIDER: S-EPMC4180829 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature