Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?

ABSTRACT:

Aims/hypothesis

South Asians are up to four times more likely to develop type 2 diabetes than white Europeans. It is postulated that the higher prevalence results from greater genetic risk. To evaluate this hypothesis, we: (1) systematically reviewed the literature for single nucleotide polymorphisms (SNPs) predisposing to type 2 diabetes in South Asians; (2) compared risk estimates, risk alleles and risk allele frequencies of predisposing SNPs between South Asians and white Europeans; and (3) tested the association of novel SNPs discovered from South Asians in white Europeans.

Methods

MEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and the Cochrane registry were searched for studies of genetic variants associated with type 2 diabetes i

SUBMITTER: Sohani ZN 

PROVIDER: S-EPMC4180911 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature