Pathway analysis of genetic factors associated with spontaneous preterm birth and pre-labor preterm rupture of membranes.

ABSTRACT:

Background

Pre-term birth (PTB) remains the leading cause of infant mortality and morbidity. Its etiology is multifactorial, with a strong genetic component. Genetic predisposition for the two subtypes, spontaneous PTB with intact membranes (sPTB) and preterm prelabor rapture of membranes (PPROM), and differences between them, have not yet been systematically summarised.

Methods and findings

Our literature search identified 15 association studies conducted in 3,600 women on 2175 SNPs in 274 genes. We used Ingenuity software to impute gene pathways and networks related to sPTB and PPROM. Detailed insight in the defined functional ontologies clearly separated integrated datasets for sPTB and PPROM. Our analysis of upstream regulators of genes suggests that glucocorticoid recep

SUBMITTER: Capece A 

PROVIDER: S-EPMC4181300 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature