Serum metabonomic analysis of protective effects of Curcuma aromatica oil on renal fibrosis rats.

ABSTRACT:

Background

Curcuma aromatica oil is a traditional herbal medicine demonstrating protective and anti-fibrosis activities in renal fibrosis patients. However, study of its mechanism of action is challenged by its multiple components and multiple targets that its active agent acts on.

Methodology/principal findings

Nuclear magnetic resonance (NMR)-based metabonomics combined with clinical chemistry and histopathology examination were performed to evaluate intervening effects of Curcuma aromatica oil on renal interstitial fibrosis rats induced by unilateral ureteral obstruction. The metabolite levels were compared based on integral values of serum 1H NMR spectra from rats on 3, 7, 14, and 28 days after the medicine administration. Time trajectory analysis demonstrated that metab

SUBMITTER: Zhao L 

PROVIDER: S-EPMC4181651 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature