Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial.

ABSTRACT:

Background

Preconception-initiated low-dose aspirin might positively affect pregnancy outcomes, but this possibility has not been adequately assessed. Our aim was to investigate whether low-dose aspirin improved livebirth rates in women with one to two previous pregnancy losses.

Methods

In this multicentre, block-randomised, double-blind, placebo-controlled trial, women aged 18-40 years who were attempting to become pregnant were recruited from four medical centres in the USA. Participants were stratified by eligibility criteria--the original stratum was restricted to women with one loss at less than 20 weeks' gestation during the previous year, whereas the expanded stratum included women with one to two previous losses, with no restrictions on gestational age or time of los

SUBMITTER: Schisterman EF 

PROVIDER: S-EPMC4181666 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature