The Testosterone Trials: Seven coordinated trials of testosterone treatment in elderly men.

ABSTRACT: Background The prevalence of low testosterone levels in men increases with age, as does the prevalence of decreased mobility, sexual function, self-perceived vitality, cognitive abilities, bone mineral density, and glucose tolerance, and of increased anemia and coronary artery disease. Similar changes occur in men who have low serum testosterone concentrations due to known pituitary or testicular disease, and testosterone treatment improves the abnormalities. Prior studies of the effect of testosterone treatment in elderly men, however, have produced equivocal results. Purpose To describe a coordinated set of clinical trials designed to avoid the pitfalls of prior studies and to determine definitively whether testosterone treatment of elderly men with low testosterone is efficacious in imp

SUBMITTER: Snyder PJ 

PROVIDER: S-EPMC4182174 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature