Expression of XPG protein in the development, progression and prognosis of gastric cancer.

ABSTRACT:

Background

Xeroderma pigmentosum group G (XPG) plays a critical role in preventing cells from oxidative DNA damage. This study aimed to investigate XPG protein expression in different gastric tissues and in patients with diverse prognoses, thus providing insights into its role in the development, progression and prognosis of gastric cancer (GC).

Methods

A total of 176 GC, 131 adjacent non-tumour tissues, 53 atrophic gastritis (AG) and 49 superficial gastritis (SG) samples were included. Immunohistochemical staining was used to detect XPG protein expression.

Results

XPG expression was significantly higher in GC tissues compared with adjacent non-tumour tissues. In the progressive disease sequence SG→AG→GC, XPG expression was significantly higher in AG and GC compared w

SUBMITTER: Deng N 

PROVIDER: S-EPMC4182552 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature