Preclinical and clinical neural network changes in SCA2 parkinsonism.

ABSTRACT:

Background

The pathophysiological changes before the presentation of clinical symptoms in parkinsonism are unclear. In this study, we investigated neural network modulations in persons in the preclinical stage of familial parkinsonism, and how the network interactions change at the clinical stage.

Methods

We performed functional MRI in a family with SCA2 mutation, including 9 asymptomatic carriers and 10 mutation carriers with parkinsonian symptoms. Functional connectivity from the posterior putamen bilaterally and rostral supplementary motor area was used to explore network interactions in the subjects.

Results

Both the asymptomatic carriers and patients had decreased connectivity within the basal ganglia-thalamus-cortical motor loop compared to controls. The asympto

SUBMITTER: Wu T 

PROVIDER: S-EPMC4182914 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature