Ontology highlight
ABSTRACT:
SUBMITTER: Cusack CL
PROVIDER: S-EPMC4183061 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Cusack Corey L CL Swahari Vijay V Hampton Henley W W Michael Ramsey J J Deshmukh Mohanish M
Nature communications 20130101
Neurons can activate pathways that destroy the whole cell via apoptosis or selectively degenerate only the axon (pruning). Both apoptosis and axon degeneration require Bax and caspases. Here we demonstrate that despite this overlap, the pathways mediating axon degeneration during apoptosis versus axon pruning are distinct. While Caspase-6 is activated in axons following nerve growth factor deprivation, microfluidic chamber experiments reveal that Caspase-6 deficiency only protects axons during a ...[more]