Diffusion tensor imaging in Alzheimer's disease: insights into the limbic-diencephalic network and methodological considerations.

ABSTRACT: Glucose hypometabolism and gray matter atrophy are well known consequences of Alzheimer's disease (AD). Studies using these measures have shown that the earliest clinical stages, in which memory impairment is a relatively isolated feature, are associated with degeneration in an apparently remote group of areas-mesial temporal lobe (MTL), diencephalic structures such as anterior thalamus and mammillary bodies, and posterior cingulate. These sites are thought to be strongly anatomically inter-connected via a limbic-diencephalic network. Diffusion tensor imaging or DTI-an imaging technique capable of probing white matter tissue microstructure-has recently confirmed degeneration of the white matter connections of the limbic-diencephalic network in AD by way of an unbiased analysis strategy kno

SUBMITTER: Acosta-Cabronero J 

PROVIDER: S-EPMC4183111 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature