Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability.

ABSTRACT: Aurora B kinase regulates the proper biorientation of sister chromatids during mitosis. Lack of Aurora B kinase function results in the inability to correct erroneous kinetochore-microtubule attachments and gives rise to aneuploidy. Interestingly, increased Aurora B activity also leads to problems with chromosome segregation, and overexpression of this kinase has been observed in various types of cancer. However, little is known about the mechanisms by which an increase in Aurora B kinase activity can impair mitotic progression and cell viability. Here, using a yeast model, we demonstrate that increased Aurora B activity as a result of the overexpression of the Aurora B and inner centromere protein homologs triggers defects in chromosome segregation by promoting the continuous disruption o

SUBMITTER: Munoz-Barrera M 

PROVIDER: S-EPMC4183290 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature