Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons.

ABSTRACT: The production of new neurons in the olfactory bulb (OB) through adulthood is a major mechanism of structural and functional plasticity underlying learning-induced circuit remodeling. The recruitment of adult-born OB neurons depends not only on sensory input but also on the context in which the olfactory stimulus is received. Among the multiple steps of adult neurogenesis, the integration and survival of adult-born neurons are both strongly influenced by olfactory learning. Conversely, optogenetic stimulation of adult-born neurons has been shown to specifically improve olfactory learning and long-term memory. However, the nature of the circuit and the synaptic mechanisms underlying this reciprocal influence are not yet known. Here, we showed that olfactory learning increases the spine dens

SUBMITTER: Lepousez G 

PROVIDER: S-EPMC4183341 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature