Resolving anatomical and functional structure in human brain organization: identifying mesoscale organization in weighted network representations.

ABSTRACT: Human brain anatomy and function display a combination of modular and hierarchical organization, suggesting the importance of both cohesive structures and variable resolutions in the facilitation of healthy cognitive processes. However, tools to simultaneously probe these features of brain architecture require further development. We propose and apply a set of methods to extract cohesive structures in network representations of brain connectivity using multi-resolution techniques. We employ a combination of soft thresholding, windowed thresholding, and resolution in community detection, that enable us to identify and isolate structures associated with different weights. One such mesoscale structure is bipartivity, which quantifies the extent to which the brain is divided into two partition

SUBMITTER: Lohse C 

PROVIDER: S-EPMC4183375 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature