Genetic risk for attention-deficit/hyperactivity disorder contributes to neurodevelopmental traits in the general population.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) can be viewed as the extreme end of traits in the general population. Epidemiological and twin studies suggest that ADHD frequently co-occurs with and shares genetic susceptibility with autism spectrum disorder (ASD) and ASD-related traits. The aims of this study were to determine whether a composite of common molecular genetic variants, previously found to be associated with clinically diagnosed ADHD, predicts ADHD and ASD-related traits in the general population.

Methods

Polygenic risk scores were calculated in the Avon Longitudinal Study of Parents and Children (ALSPAC) population sample (N = 8229) based on a discovery case-control genome-wide association study of childhood ADHD. Regression analyses were used to a

SUBMITTER: Martin J 

PROVIDER: S-EPMC4183378 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature