A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice.

ABSTRACT:

Aims/hypothesis

The CD40-CD154 interaction directs autoimmune inflammation. Therefore, a long-standing goal in the treatment of autoimmune disease has been to control the formation of that interaction and thereby prevent destructive inflammation. Antibodies blocking CD154 are successful in mouse models of autoimmune disease but, while promising when used in humans, unfortunate thrombotic events have occurred, forcing the termination of those studies.

Methods

To address the clinical problem of thrombotic events caused by anti-CD154 antibody treatment, we created a series of small peptides based on the CD154 domain that interacts with CD40 and tested the ability of these peptides to target CD40 and prevent type 1 diabetes in NOD mice.

Results

We identified a lead candid

SUBMITTER: Vaitaitis GM 

PROVIDER: S-EPMC4183717 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature